The Database of Antimicrobial Activity and Structure of Peptides (DBAASP) has been created to provide users with detailed information on experimentally tested peptides regarding their chemical structure and activity against specific targets. The database is manually curated and contains information on ribosomal, nonribosomal, and synthetic peptides that show antimicrobial activity as Monomers, Multimers, and Multi-Peptides.

National Institute of Allergy and Infectious Diseases

Data Discovery Engine

infectious disease

Data Discovery Engine, NIAID Data Ecosystem

Bacteria

Fungi

Minimum Inhibitory Concentration Test

cytotoxicity assay

3D structure prediction

Database of Antimicrobial Activity and Structure of Peptides

Viruses

Conditions of use

The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. In addition to capturing the core data mandatory for each UniProtKB entry (mainly, the amino acid sequence, protein name or description, taxonomic data and citation information), as much annotation information as possible is added. This includes widely accepted biological ontologies, classifications and cross-references, and clear indications of the quality of annotation in the form of evidence attribution of experimental and computational data. The UniProt Knowledgebase consists of two sections: a reviewed section containing manually-annotated records with information extracted from literature and curator-evaluated computational analysis (aka "UniProtKB/Swiss-Prot"), and an unreviewed section with computationally analyzed records that await full manual annotation (aka "UniProtKB/TrEMBL").

European Molecular Biology Laboratory

Alzheimer's Research UK

Biotechnology and Biological Sciences Research Council

State Secretariat for Education, Research and Innovation

National Institute of General Medical Sciences

National Library of Medicine

and the National Science Foundation

National Eye Institute

National Human Genome Research Institute

National Heart, Lung, and Blood Institute 

National Institute on Aging

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Mental Health

National Cancer Institute

Curation

UniProt

Fairsharing.org

"The Human Immunology Project Consortium (HIPC) program was established in 2010, and renewed in 2015 and in 2022, by the NIAID Division of Allergy, Immunology, and Transplantation as part of the overall NIAID focus on human immunology. Through this program, well-characterized human cohorts are studied using a variety of modern analytic tools, including multiplex transcriptional, cytokine, and proteomic assays; multiparameter phenotyping of leukocyte subsets; assessment of leukocyte functional status; and multiple computational methods. 

Through the HIPC program, centralized research resources and a comprehensive, centralized database will be constructed for use by the greater scientific community. The information gained from the HIPC program will provide a comprehensive understanding of the human immune system and its regulation and will reveal novel associations between components of the immune system and other biological systems, identify novel immune mediators and pathways, establish predictors of vaccine safety in different populations, and enable the rapid evaluation of different vaccine formulations and administration regimens in human populations. This knowledge base will also serve as a foundation for the future study of immune-mediated diseases in the human, such as allergy, asthma, transplant rejection, autoimmune diseases, and a variety of inflammatory diseases."

allergic disease

asthma

autoimmune disease

Flow Cytometry

Mass Cytometry

Mass Spectrometry

transcription profiling assay

ImmuneSpace

Homo sapiens

The NIAID TB Portals Program is a multi-national collaboration for tuberculosis (TB) data sharing and analysis to advance TB research. As a global consortium of clinicians, scientists, and IT professionals, we built the TB Portals, a web-based, open-access repository of multi-domain TB data and tools for its analysis. Here, you can find linked socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from over 11400 international TB patient cases. You can explore and analyze these data through any of our tools, focusing on only one domain or across all of them. TB Portals data are also available for download to support your own research.

NIAID

tuberculosis

Mycobacterium tuberculosis

Imaging

Whole genome sequencing

clinical data

TB Portals

TB Portals Data Use Agreement

The Immune Epitope Database (IEDB) is a freely available resource funded by NIAID. It catalogs experimental data on antibody and T cell epitopes studied in humans and other animal species in the context of infectious disease, allergy, autoimmunity and transplantation. The IEDB also hosts epitope prediction and analysis tools, and has a companion site, CEDAR (funded by NCI), which houses cancer epitopes.

T-cell assays

B-cell assays

Major histocompatibility complex binding assays

literature curation

computational method

Immune Epitope Database

FAIRsharing.org

Mus musculus

CC-BY

NCBI Virus is a community portal for viral sequence data from RefSeq, GenBank and other NCBI repositories.

Severe acute respiratory syndrome coronavirus 2

sequencing assay

digital curation

NCBI Virus

re3data.org

cellular organisms

ITN TrialShare shares information about ITN's clinical studies and specimen bio-repository. Data and analysis code underlying ITN-published manuscripts are publicly available with the goal of promoting transparency, reproducibility, and scientific collaboration.

cytometry assay

flow cytometry assay

Immune Tolerance Network TrialShare Clinical Trials Research Portal

ACTG is a global clinical trials network that conducts research to improve the management of HIV and its comorbidities; develop a cure for HIV; and innovate treatments for tuberculosis, hepatitis B, and emerging infectious diseases. ACTG is the world’s largest and longest running clinical trials network focused on HIV and other infectious diseases and the people living with them. Founded in 1987, it comprises thousands of dedicated researchers, staff, and community members who are pursuing research into novel treatments and cures for infectious diseases at 65 locations across four continents, with the ultimate goal of advancing science that meaningfully impacts the lives of the people we serve.

NIDA

NINDS

AIDS

Human immunodeficiency virus 1

Human immunodeficiency virus 2

Clinical Trial

AIDS Clinical Trials Group

The overall mission of the HMP was to generate resources to facilitate characterization of the human microbiota to further our understanding of how the microbiome impacts human health and disease. The initial phase of the project, HMP1, established in 2008, characterized the microbial communities from 300 healthy individuals, across several different sites on the human body: nasal passages, oral cavity, skin, gastrointestinal tract, and urogenital tract. 16S rRNA sequencing was performed to characterize the complexity of microbial communities at each body site, and to begin to ask whether there is a core healthy microbiome. Metagenomic whole genome shotgun (wgs) sequencing provided insights into the functions and pathways present in the human microbiome. The second phase of the HMP, the iHMP, will create integrated longitudinal datasets from both the microbiome and host from three different cohort studies of microbiome-associated conditions using multiple ‘omics technologies. Each of these study groups has engaged in providing new computational tools and integrative molecular perspectives on microbial activity during dysbiosis. As a result of creating these multi’omic data resources, the iHMP has opened up new opportunities for data integration in the human microbiome.

NIH Office of the Director

National Center for Complementary and Integrative Health

dysbiosis

inflammatory bowel disease

type 2 diabetes mellitus

Pregnancy

Pregnancy Outcome

Preterm Birth

16S metagenomic sequencing

Longitudinal Study

liquid chromatography-mass spectrometry

Metabolomics

Transcriptomics

Clinical Observation

Human Microbiome Project Portal

The Bacterial and Viral Bioinformatics Resource Center (BV-BRC) is an information system designed to support research on bacterial and viral infectious diseases. The BV-BRC combines the data and tools from the Legacy BRC resources: PATRIC, the bacterial BRC, and IRD and ViPR, the viral BRCs.

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